Key-bindings!

This is an article for those newer to the MMO scene, if you're a seasoned veteran, feel free to skip on over this one. ;)

If you decide to start using keybindings (yaaaaaaay), then you may need a little help getting started!

Generally I'll keep the 1-5, and maybe 6 as I have semi-long fingers. But 7-0 are a nono. They're awkward and hard to hit. Modifiers for 1-5 are the easiest of the bindings, Alt 1-5, Shift 1-5, Control 1-5, etc.

After this you can use mouse buttons if you have a fancy enough mouse. I find middle mouse to be simple enough, just press it down and boom, a simple and easy to use new keybinding. If you have buttons on the side, i.e. mouse buttons 4 and 5, you can use those as well. They may also easily be used with modifiers, although it takes a while to get used to. For example, I use Shift, Control, and Alt-middle click for 3 different abilities, the same can go for mouse buttons 4-5.

If you're already used to in-game interface bindings, using C to open the character tab for example, then using the unused or worthlessly bound letters can be to your advantage. For example I always use G to use my mount, R for auto run, etc. I also use modifiers for these. Shift-G was my Adrenaline Rush in WoW, Shift-R was reply to a whisper, Control-R was Rupture. I even had a few obscure ones bound, such as Shift-H, Shift-Y, Control-B, etc.

~ is also a fantastic and easy to use keybinding, as it is right next to 1, anyway. Caps lock is my teamspeak microphone binding if that's useful to you.

Now if you want to get REALLY deep into bindings, give a look at both the Razer Naga and the Razer Nostromo pad.

The naga alone knocks mouse-bindings up a notch with TWELVE buttons on the side, instead of the normal 2 of your average gamer mouse. These are somewhat easy to bind and come in very handy. The nostromo is a little more complex. It replaces your keyboard almost completely in combat type situations. Everything is close together, making for fast reactions and swift keybindings, if you're used to it.

Here's an oldie but a goodie review on a nostromo type device: 

My closing advice is to start off small with the 1-5, then modifiers of 1-5 and some mouse buttons thrown in if you have them. Work your way up, and don't be afraid to try new things!